Unlocking the true power of CRISPR for molecular detection.

Activation begins with specific detection of a nucleic acid target that results in a positive signal amplification feedback loop, producing analytical reaction times in mere minutes.

Unlike PCR or other DNA/RNA amplification technologies, the CRISPR Cascade enables high performance, highly scalable and rapid assays, while allowing pooling of multiple targets within reactions, akin to a molecular switch, allowing for massive multiplexing.

The combined use of engineered CRISPR enzymes, blocked sequences, and reporter molecules generates robust signal without target amplification.

With a generally applicable signal amplification for DNA or RNA, rapid product development can be achieved with simple target sequence selection and optimization.